Correlation of the SNPs with the lowest p-value in each cluster of SNPs reaching genome-wide significance in CARe to SNPs reaching genome-wide significance in previous European and Asian studies.

Correlations were examined in the following samples from HapMap phase II (release 22) or HapMap phase III (release 2): CEU – Utah residents with northern and western European ancestry from the CEPH collection, YRI – Yoruba in Ibadan, Nigeria, ASW – African ancestry in southwestern USA, LWK – Luhya in Webuye, Kenya, MKK – Maasai in Kinyawa, Kenya. The strongest SNP in SCN5A in European studies (rs11708996) is monomorphic in YRI and was not genotyped in HapMap phase III. The SNP downstream of TBX5 described in Pfeufer et al is >500 kb from the other two SNPs, that are located within the gene. The correlation of the two previously described SNPs in SCN10A is 0.97 in CEU. The correlation of our two SNPs in SCN5A is 0.001 in CEU, 0.27 in YRI, 0.19 in ASW, 0.03 in LWK and 0.05 in MKK.