Randomization CRF in ATN 143: Comparison of Men's Prevention Apps to Research Efficacy

Data From Randomization CRF
Study Description
COMPARE was part of the iTech NIH U19, which had an overall goal to develop innovative technology-focused interventions addressing the HIV prevention and care continuum for youth. In years 1-2 of the grant, the investigators optimized and pilot tested using a similar study design and identical study outcomes, two distinct mobile apps called LYNX and MyChoices. Each app was designed to increase HIV testing and PrEP uptake among YMSM. In this study, the individual apps were tested in a follow-on research study and evaluated for efficacy. YMSM were randomized to receive either MyChoices, LYNX, or SOC. It included three major functions that were designed to promote self-efficacy, self-regulation, goal-setting and environmental influences to impact behavior change. Compared to standard of care (59%), participants randomized to MyChoices (74%; p=.010) were more likely to have received at least one HIV test over 6 months of follow up; those randomized to LYNX also had higher proportion of testing (70%) but it was marginally statistically different (p=.078). While participants in both MyChoices (21%) and LYNX (20%) arms had higher rates of starting PrEP compared to SOC (16%), these differences were not significant (p=.516). Given the ubiquity of mobile app use and modest resources required to scale this intervention, a 25% relative increase in HIV testing among YSMM, as seen in this study, could facilitate curtailment of the epidemic in the U.S. and even globally. 381 participants were enrolled, subject responses based on Baseline Survey.