Protection-Group-Free Semisyntheses of Parthenolide and Its Cyclopropyl Analogue
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https://figshare.com/articles/dataset/Protection_Group_Free_Semisyntheses_of_Parthenolide_and_Its_Cyclopropyl_Analogue/2364988
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资源简介：
Parthenolide
showed extensive bioactivities including selective eradication of
AML stem cells. Herein we report protection-free semisyntheses of
parthenolide and its cyclopropyl analogue (compound 10) from the abundant natural product costunolide with an overall yield
of 55 and 60%, respectively. Compound 10 was more stable
than parthenolide, and it maintained comparable activities against
AML cell lines and AML stem cells. Therefore, compound 10 might be a superior small molecule than parthenolide as a tool for
investigation of cancer stem cell biology.
创建时间：
2016-02-18
