NHLBI TOPMed: Trans-Omics for Precision Medicine (TOPMed) Whole Genome Sequencing Project: Cardiovascular Health Study

Participants from the Cardiovascular Health Study (CHS), a large population-based longitudinal cohort study ([phs000287](study.cgi?study_id=phs000287)), have been included in the TOPMed project. Whole genome sequencing will be performed to contribute to multiple analyses, including cardiovascular disease risk factors, subclinical disease measures, the occurrence of myocardial infarction (MI) and stroke, and analyses of venous thromboembolism (VTE).

Comprehensive phenotypic and pedigree data for study participants are available through dbGaP [phs000287](https://www.ncbi.nlm.nih.gov/gap/advanced_search/?TERM=phs000287).