Immune transcriptome in adult-onset Still's disease with mild flare following administration of mRNA vaccine BNT162b2

Adult-onset Still's disease (AOSD) patients represent a population for which vaccination can induce disease flare1. The COVID-19 pandemic vaccination programs presented these patients and their health care providers with a critical decision. Previously it has been described that AOSD patients can experience disease flare with COVID-19 vaccination but no one has yet reported their immune transcriptional and antibody response. Here we present the transcriptional response and anti-spike antibody profile of a 58-year-old male after vaccination with BNT162b2 who experienced a mild AOSD flare following the second vaccine. Overall design: RNA-seq were performed with peripheral blood mononuclear cells (PBMCs) from AOSD patient who had received the BNT162b2 mRNA vaccine.