Peptide Sequence

Fetal development and parturition are precisely regulated processes that involve continuous crosstalk between the mother and fetus. Our previous studies have shown that fetal lung-derived factors may play important roles in signaling the initiation of maternal delivery. However, whether fetal lung development is associated with initiation of labor has yet been elucidated. In present study, we performed RNA-seq analysis combined with targeted metabolomics analysis of the fetal lungs, in a delayed labor mouse model, steroid receptor coactivator (SRC)1/SRC2 double knockout (dKO) mouse. It was found that the expression of arginase 1 (Arg1), the key enzyme in arginine biosynthesis and metabolism, was significantly decreased in the SRC1/SRC2 dKO mice, along with the increased levels of the Arg1 substrate arginine and decreased levels of the Arg1 metabolite ornithine.