Ru(II)/Ir(III)-Catalyzed C–H Bond Activation/Annulation of Cyclic Amides with 1,3-Diketone-2-diazo Compounds: Facile Access to 8H‑Isoquinolino[1,2‑b]quinazolin-8-ones and Phthalazino[2,3‑a]cinnoline-8,13-diones

Efficient
access to 8H-isoquinolino­[1,2-b]­quinazolin-8-ones
and phthalazino­[2,3-a]­cinnoline-8,13-diones through
cyclic amide-directed Ru­(II)/Ir­(III)-catalyzed
C–H bond activation, has been developed. Consecutive C–H
bond activation, carbene insertion, and condensation annulation processes
were realized, affording 8H-isoquinolino­[1,2-b]­quinazolin-8-one and phthalazino­[2,3-a]­cinnoline-8,13-dione derivatives in good-to-excellent yields under
mild conditions, with H2O and N2 being generated
as the only byproducts.

通过环酰胺导向的Ru(II)/Ir(III)催化的C-H键活化，成功开发了一种高效获取8H-isoquinolino[1,2-b]quinazolin-8-ones和phthalazino[2,3-a]cinnoline-8,13-diones的方法。该方法实现了连续的C-H键活化、碳负离子插入及缩合环化反应过程，在温和条件下以良好的至优异的产率合成了8H-isoquinolino[1,2-b]quinazolin-8-one和phthalazino[2,3-a]cinnoline-8,13-dione衍生物，且仅生成H2O和N2作为副产物。