Design, Synthesis, and Biological Evaluation of MEK PROTACs
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下载链接：
https://figshare.com/articles/dataset/Design_Synthesis_and_Biological_Evaluation_of_MEK_PROTACs/11413149
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资源简介：
PROteolysis TArgeting Chimeras (PROTACs) targeting the
degradation
of MEK have been designed based on allosteric MEK inhibitors. Inhibition
of the phosphorylation of ERK1/2 was less effective with the PROTACs
than a small-molecule inhibitor; the best PROTACs, however, were more
effective in inhibiting proliferation of A375 cells than an inhibitor.
创建时间：
2019-12-05
