Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.
收藏PubMed Central1992-11-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC50473/
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资源简介：
The random addition of "N nucleotides" by terminal deoxynucleotidyltransferase (TdT) is an important component of the diversity of T-cell receptor genes. We have investigated the expression of TdT during thymocyte differentiation and thymus ontogeny. TdT gene transcripts are confined to immature thymocytes of the cortex, being down-regulated concomitantly with recombination-activating gene transcripts after positive selection of mature medullary T cells. According to in situ hybridization, TdT RNA is absent from the neonatal thymus, but it appears 3 to 5 days after birth, just before the appearance of significant N-region diversity in T-cell receptor junctional sequences but clearly after the thymus attains competence at clonal deletion. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1992-11-15
