RNA-Seq of MCF7 intraductal xenografts hormonally treated

Using a large variety of methods we demostrate that PGR can be a driver of tumor proliferation even in absence of extensive E2. In this specific experiment we treat MCF7 cells intraductally xenografted into the ductal tree of a mouse mammary gland, with estrogen (E2), progesterone (P4) and the combination of the two (E2+P4). MCF7 cells were grown intraductally for 45 days. 7 days after injection hormone pellets were implanted subcutaneously.