Thermodynamics of 5-Helix binding and HIV-1 neutralization activity.
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aITC measurements were carried out at 28°C in 10 mM Tris buffer, pH 7.5, 150 mM NaCl.
bHIV-1 neutralization activity was measured using an Env-pseudotyped virus neutralization assay as described previously [39] with Envs from four HIV-1 subtype B laboratory-adapted strains, HXB2, SF162, JR CSF and 89.6. Fabs 8066 and 8062 are in monovalent format.
cNA, no activity. Neutralization was too weak to reliably determine an IC50.
创建时间：
2010-11-11
