Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2)
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Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2) Descriptor: 3-[3-[[1-[(3~{S})-2,6-bis(oxidanylidene)piperidin-3-yl]-2,5-bis(oxidanylidene)pyrrol-3-yl]amino]phenyl]-~{N}-(3-chloranyl-4-methyl-phenyl)propanamide, DNA damage-binding protein 1, Protein cereblon, ... Authors: Nowak, R.P, Fischer, E.S. Deposit date: 2021-02-12 Release date: 2021-06-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.78 Å) Cite: Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol., 17, 2021
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2021-02-12
