Whole exome sequencing of tumors of the ampulla of Vater by next-generation sequencing methods

Ampullary carcinomas are highly malignant neoplasms that can have either intestinal or pancreatobiliary differentiation. To characterize somatic alterations in ampullary carcinomas, we performed whole-exome sequencing on 60 ampullary carcinomas resected from clinically well-characterized Japanese and American patients. The Data Access Committee of the National Bioscience Database Center (NBDC) approved that this personal genetic data were made published according to NBDC data sharing guidelines (http://humandbs.biosciencedbc.jp/).