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A specific RIP3+ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism. A specific RIP3+ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism

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NIAID Data Ecosystem2026-03-11 收录
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To elucidate the classification and function of microglia subsets in the angiogenic retina, we used single-cell RNA sequencing on isolated retinal microglia. We identified a novel subpopulation of microglia named sMG2, which highly expressed necroptosis-related genes Rip3 and Mlkl. Overall design: Single cell profiling of retinal microglia from normal and oxygen-induced retinopathy mice, using 10X genomic platform.

创建时间:
2020-06-22
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