Proteins identified from the 2D-DIGE (pH 3–10) analysis of mouse brain lysates collected at early (E), late paralytic (LP) or late tetanus-like (LT) time-points after CHIKV infection.

The proteins were identified by mass spectrometry following in-gel trypsin digestion. The spot numbers correspond to the same numbers as indicated on Figure 2. The identities of the spots, their SwissProt accession numbers, and the theoretical molecular masses and pI values as well as the number of peptide sequences, the corresponding percent sequence coverage, and the Mascot score are listed for MS/MS analysis. Protein scores greater than 35 were considered as significant (p). Paired average volume ratio and p-values (ANOVA) between each paired groups compared, were defined using Progenesis Samespot software. n.i., no identification.M; mock-infected samples.