The glomerular circadian clock temporally regulates basement membrane dynamics and glucocorticoid response. Cultured podocyte cells circadian clock

Kidney physiology has diurnal variation and abnormal circadian rhythm is associated with kidney disease. However, it is not known whether glomeruli, the filtering units in the kidney, are under circadian control. We therefore investigated core circadian clock components in cultered podocyte cells, together with their rhythmic targets and modes of regulation.