The basis for natural multiresistance to phage in Pseudomonas aeruginosa. Pseudomonas aeruginosa strains extremely resistant to phages

We investigated the characteristics of three Pseudomonas aeruginosa clinical strains naturally resistant to phages belonging to ten different genera. These strains spontaneously release phages and pyocins, and form colonies with a rough aspect. Their genome was completely sequenced showing the presence of multiple prophages, insertion elements, genomic islands, in sharp contrast with the genomes of two strains highly sensitive to phages.