PDB files on phosphorylation effects on Y14

The C-terminus of the Y14 protein, also known as RBM8A, encoded by the gene responsible for human thrombocytopenia absent radius syndrome, contains two serines that undergo phosphorylation inside an intrinsically disordered region (IDR). Although both serines are frequently phosphorylated in cells, their biological role remains unclear. Therefore, we estimated peptide structure using PEPstrMOD, which predicts peptide conformations through molecular dynamics. For the analysis, amino acid residues 151–174 of Y14, identified as an IDR in UniProt, were targeted. The prevalence of phosphorylated Y14 in cells may indicate that this higher-order structure is also essential for mRNA metabolism. Structural coordinate files (PDB format) obtained for models 1 to 5 are deposited.