STAMPEED: Myocardial Infarction Genetics Consortium (MIGen)

Myocardial infarction (MI) is a common complex disease and the leading cause of death and disability worldwide. The genetic basis of this disease is largely unknown. It has been thought that early-onset MI events would have a substantially greater heritability, thus making DNA collections with younger individuals desirable. More recently, genome-wide association studies have become feasible through the development of whole genome arrays and a large catalogue of common variants reported in the International HapMap database. This study aims to use Affymetrix genotyping platform to do a whole genome scan in 3000 early-onset MI cases and 3000 matched controls from 6 study collection sites.]]>
There were 2,967 cases and 3,075 controls run on Genome-Wide Human SNP Array 6.0 and analyzed for association testing. The age criteria for the cases was men ≤50 y old or women ≤60 y old. The samples were drawn from 6 collection sites: Boston, MA (Masschusetts General Hospital Premature Coronary Artery Disease Study), Seattle, WA (Heart Attack Risk in Puget Sound), Helsinki, Finland (FINRISK), Malmö, Sweden (Malmö Diet and Cancer Study), Barcelona, Spain (REGICOR), and Milan, Italy (Italian Atherosclerosis Thrombosis and Vascular Biology Working Group).]]>