Cardiac gene expression and plasma biomarkers in adult WT and CX3CR1 KO mice exposed to adolescent stress and/or alcohol: Data for correlation analyses

Adolescence is a vulnerable window in which stress and alcohol can induce long-lasting neuroimmune and cardiovascular alterations. The fractalkine axis (CX3CL1/CX3CR1) regulates microglia–neuron communication and inflammatory tone, but its contribution to linking adolescent exposures with adult anxiety-like behavior and cardiac injury is unclear. Male and female wild-type (WT) and CX3CR1 knockout (KO) C57BL/6J mice underwent restraint stress, ethanol (2 g/kg, i.p., 14 days), their combination, or control handling. In adulthood, plasma cardiac troponins I/T, CX3CL1, ACTH, and corticosterone were quantified; and cardiac expression of chemokine, proinflammatory, stress-receptor, and renin–angiotensin–aldosterone system (RAAS)-related genes was profiled. Rho correlation coefficient and p-values were calculated from raw data.