Expression Profile of Genes in Trabecular Meshwork Cells Treated with Dexamethasone. Expression Profile of Genes in Trabecular Meshwork Cells Treated with Dexamethasone

Treatment with glucocorticoids is known to cause ocular hypertension in humans which can lead to steriod-induced glaucoma We used microarrays to determine changes in gene expression in two human trabecular meshwork (TM) cell isolates (TM-4 and TM-2) from the same donor that could explain the increase in ocular hypertension. Overall design: RNA was extracted from confluent cultures of trabecular meshwork cells treated with and without dexamethasone (DEX) for 6 days and prepared for hybridization on Affymetrix microarrays