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Conserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response

ChEBI2015-05-01 更新2026-07-21 收录

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-53732 数据链接链接失效反馈

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Conserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response

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2015-05-01

长寿研究

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Intensive research efforts have been undertaken to slow human aging and therefore potentially delay the onset of age-related diseases. These efforts have generated an enormous amount of high-throughpu

NIAID Data Ecosystem50

Innate immunity in the C. elegans intestine is programmed by a neuronal regulator of AWC olfactory neuron development

神经免疫调控

线虫先天免疫

Olfactory neurons allow animals to discriminate nutritious food sources from potential pathogens. From a forward genetic screen, we uncovered a surprising requirement for the olfactory neuron gene olr

NIAID Data Ecosystem30

Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants (ETC_Mutants)

酵母衰老模型

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Here we sought to comprehensively characterize the role of the electron transport chain in yeast models of aging. Using a panel of ETC mutants, we observed that ETC mutants fail to survive starvation

NIAID Data Ecosystem30

Conserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response

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Discriminating pathogenic bacteria from energy-harvesting commensals is key to host immunity. Using mutants defective in the enzymes of O-linked N-acetylglucosamine (O-GlcNAc) cycling, we examined the

NIAID Data Ecosystem40

Transcripts regulated by elevated DKF-2 (WT background). Caenorhabditis elegans

线虫先天免疫

转录调控

Transcriptional profiling was used to determine why DKF-2 (protein kinase D) deficiency and surfeit caused hypersensitivity and resistance, respectively, to a bacterial pathogen (P. aeruginosa 14). Th

NIAID Data Ecosystem30

Conserved nutrient sensor O-GlcNAc transferase is integral to the C. elegans pathogen-specific immune response

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