Every laboratory performing mass-spectrometry-based proteomics strives to generate high-quality data. Among the many factors that impact the outcome of any experiment in proteomics is the LC–MS system

NIAID Data Ecosystem30

Table_2_Phosphorylation Modifications Regulating Cardiac Protein Quality Control Mechanisms.XLSX

蛋白质质量控制

磷酸化修饰

Many forms of cardiac disease, including heart failure, present with inadequate protein quality control (PQC). Pathological conditions often involve impaired removal of terminally misfolded proteins.

NIAID Data Ecosystem10

RqcH and RqcP catalyze processive poly-alanine synthesis. RqcH and RqcP catalyze processive poly-alanine synthesis

蛋白质质量控制

多聚丙氨酸合成机制

In the cell, stalled ribosomes are rescued through ribosome-associated protein quality-control (RQC) pathways. We demonstrate that RqcH is responsible for tRNAAla selection during RQC elongation, wher

NIAID Data Ecosystem60

EDEM2 and OS-9 Are Required for ER-Associated Degradation of Non-Glycosylated Sonic Hedgehog

内质网相关降解

蛋白质质量控制

Misfolded proteins of the endoplasmic reticulum (ER) are eliminated by the ER-associated degradation (ERAD) in eukaryotes. In S. cerevisiae, ER-resident lectins mediate substrate recognition through b

Figshare2016-01-15 更新20

IRE1alpha is an endogenous substrate of endoplasmic reticulum-associated degradation

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