WT1

We analyzed gene expression in lung tissue from <em>Calca+</em>/- and WT rats using RNA-seq, and subsequent Gene Ontology (GO) analysis showed that nucleus and cytoplasm expression pathways were significantly enriched in <em>Calca</em>+/- rats compared to WT, indicating that αCGRP deficiency may induce specific proteins target intranuclear and cytoplasmic migration

我们采用RNA测序（RNA-seq）技术，对<em>Calca+</em>/-与野生型（Wild Type, WT）大鼠的肺组织基因表达水平展开分析。后续的基因本体论（Gene Ontology, GO）分析结果显示，相较于野生型大鼠，<em>Calca</em>+/-大鼠中与细胞核及细胞质相关的表达通路显著富集，这表明α降钙素基因相关肽（α-calcitonin gene-related peptide, αCGRP）的缺失可能会诱导特定蛋白靶向细胞核与细胞质的迁移。