Plling et al. 2017 UKB parents attained age GWAS

Analysis of genotypes associated with parents attained age (lifespan) in the UK Biobank. If used please reference:<br><br><b>Pilling et al. 2016. Human longevity: 25 genetic loci associated in 389,166 UK biobank participants. Aging US<br></b>http://www.aging-us.com/article/101334/text<br><br>Results are from BOLT-LMM analysis of European participants, adjusted for age, sex, assessment centre and array type.<br><br>7 phenotypes:<br>* Mothers age at death<br>* Fathers age at death<br><br>* Mothers attained age (including alive parents)<br>* Fathers attained age (including alive parents)<br><br>* Combined parents age at death<br>* Combined parents attained age (including alive parents)<br><br>* [Binary] both parents reached top 10% of survival (&gt;=90 mothers, &gt;=87 fathers) vs. both parents died before age 80<br><br>&gt;&gt; For each analysis there is an accompanying GIV dataset. The UK Biobank sample was randomly split in half, and the analysis repeated. This is for use in Genetic Instrumental Variable (GIV) Regression analysis.<br><br>Fields are as follows<br> SNP: dnSNP name of genetic marker, if available<br> CHR: chromosome<br> BP: base-pair position on CHR (hg19 / b37)<br> ALLELE1: effect allele<br> ALLELE0: non-effect allele<br> A1FREQ: frequency of ALLELE1<br> BETA: effect size from BOLT-LMM approximation to infinitesimal mixed model<br> SE: standard error of effect size<br> P_BOLT_LMM: non-infinitesimal mixed model association test p-value