circRNA high-throughput sequencing of 3 pairs of breast cancer tissues

CircRNAs are a group of endogenous small noncoding RNAs that are involved in multiple diseases including cancers. At present, the functions of circRNAs in breast cancer need to be further explored. In this study, 3 pairs of breast cancer tissues with axillary lymph node metastasis were collected for circRNA high-throughput sequencing. We have identified 17966 distinct circRNA candidates. Significant differential expressions were found in 136 circRNAs in breast cancer tissues relative to the matched paracancer tissues.