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Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant

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Protein Data Bank Japan2024-01-24 更新2026-03-21 收录
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Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, CITRIC ACID, ... Authors: Schoppe, J, Ehrenmann, J, Klenk, C, Rucktooa, P, Schutz, M, Dore, A.S, Pluckthun, A. Deposit date: 2018-09-11 Release date: 2019-01-16 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nat Commun, 10, 2019
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2018-09-11
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