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Three-Component Synthesis of α,β-Cyclopropyl-γ-Amino Acids

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NIAID Data Ecosystem2026-03-06 收录
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The multicomponent coupling of alkenylzirconocenes with N-diphenylphosphinoyl imines provides rapid access to functionalized C-cyclopropylalkylamides which have been readily transformed into α,β-cyclopropyl-γ-amino acids. These novel scaffolds are thus accessible in ca. 8 steps from commercially available alkynes.

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2016-05-06
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