File S1 - Effects of Prolonged Exposure to Hypobaric Hypoxia on Oxidative Stress, Inflammation and Gluco-Insular Regulation: The Not-So-Sweet Price for Good Regulation

Supporting information figure and tables. Figure S1, Cumulative mean changes in body weight occurred at the end of the Caudwell Everest Expedition in climbers and in members residing at base camp (EBC). Mann-Whitney test was used to determine between-group differences in weight loss after EBC 8 weeks. Table S1, Ascent profile and residence at high altitude of the team remaining at Everest Base Camp (EBC, N = 10) and those climbing higher (Climbers, N = 14)*. Information on altitude (m), barometric pressure (mmHg) and inspired partial pressure of oxygen (PiO2, mmHg) is reported for each phase. Hemoglobin concentrations (g/dl) and arterial oxygen saturation (SaO2, %) are reported in each group during the different phases of the expedition. Table S2, Summary of the number of samples included in the analyses for each biomarker. Table S3, Correlation matrix to look at association between biomarkers of inflammation, oxidative stress and counter-regulatory hormones with glucose, insulin, C-peptide and HOMA-R. (DOCX)