Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

We performed T cell receptor (TCR) sequencing to study immune cell composition and (hyper-)expansion of circulating and joint-derived Tregs and non-Tregs in Juvenile Idiopathic Arthritis (JIA, N=9). We studied different joints affected at the same time, as well as over the course of relapsing remitting disease. Overall design: Examination of circulating and joint derived (regulatory) T cell receptors from JIA patents