Genome-wide ETS-1 binding profile to chromatin in human CD4+ T lymphocytes [ChIP-seq]

In response to pathogenic threats, naïve T cells rapidly transition from a quiescent to activated state, yet the underlying mechanisms are incompletely understood. We investigated the dynamics of mRNA translation kinetics and protein turnover in human naïve and activated T cells. Our datasets uncovered that transcription factors maintaining T cell quiescence had constitutively high turnover, which facilitated their depletion upon activation. Our data elucidate new insights into how T cells maintain a prepared state to mount a rapid immune response. ETS-1 binding profile (ChIP-seq) in human CD4+ T lymphocytes ex-vivo isolated from the peripheral blood of three healthy donors.