Antibacterial and anticancer activities of green-synthesized silver nanoparticles using<i> </i><i>Photinia glabra</i> fruit extract

<b>Aims: </b>We prepared <i>Photinia glabra </i>(PG) aqueous fruit extract, utilized it to synthesize silver nanoparticles (PG-Ag NPs) and evaluated the antibacterial and anticancer activities of the nanoparticles (NPs). <b>Materials &amp; methods: </b>Silver nitrate aqueous solution was reduced to PG-Ag NPs using aqueous PG fruit extract. NP shape, size, composition and functionalization were determined using transmission electron microscopy, x-ray photoelectron spectroscopy, Fourier transform infrared and x-ray diffraction. <b>Results &amp; conclusions: </b>PG-Ag NPs were spherical, approximately 39–77 nm-sized, furctionalized surfaces with notable antibacterial activity against both <i>Escherichia coli </i>and <i>Staphylococcus aureus, </i>with an MIC <b>&lt;</b>30 ug<b>/</b>ml and cytotoxicity toward esophageal cancer cells, with IC50 values less than 20 ug<b>/</b>ml. PGAg@ rt NPs have been shown to be a potent antibacterial and anticancer agent, and their enriched particle surfaces can be conjugated with other compounds for multibiomedical applications.