Implantable wireless optoelectronic devices for cancer surgical guidance and treatment

The limited depth penetration of light in tissue, caused by absorption and multiple scattering, is a major challenge for its use in diagnostics and treatment in vivo. To overcome this limitation, we have created a new platform of wirelessly powered implantable devices that can be injected into the body using a standard biopsy needle. In this dissertation, we developed versions of the device that can be used to improve the localization of non-palpable breast cancers during lumpectomy surgeries and to perform photoactivated therapy in deep tissue. The devices are equipped with wirelessly powered light-emitting diodes (LEDs), encapsulated in a biocompatible epoxy, and include an impedance-matching circuit and a miniature receiver coil optimized for wireless operation in the 6.78 MHz industrial, scientific, and medical (ISM) radiofrequency (RF) band. For surgical applications, the device is multi-colored to take advantage of the wavelength-dependence of light attenuation and provide the surgeon with precise visual position and distance guidance based upon changes in perceived color. Specifically, due to the significant differences in tissue optical absorption, the implant contains a red LED that is visible through thick tissue (several cm), while a blue LED is mainly visible superficially (

组织内光线因吸收和多次散射而有限的深度穿透，成为其在体内诊断和治疗中的主要挑战。为了克服这一限制，我们开发了一种新型无线供电的植入式设备平台，该设备可通过标准活检针注入体内。在本论文中，我们开发了可用于在乳房切除术期间改善不可触及乳腺癌定位以及进行深层组织光激活治疗的设备版本。这些设备配备了无线供电的发光二极管（LED），封装在生物相容性环氧树脂中，并包括一个阻抗匹配电路和用于6.78 MHz工业、科学和医疗（ISM）射频（RF）带的微型接收线圈，以优化无线操作。对于手术应用，设备采用多色设计，以利用光衰减的波长依赖性，并为外科医生提供基于感知颜色变化的精确视觉定位和距离引导。具体而言，由于组织光学吸收的显著差异，植入物中包含一个可见于厚组织（数厘米）的红光LED，而蓝光LED主要在表层可见（mainly visible superficially）。