Gene expression modification in lungs of rats exposed to Mitsui-7 and NM-403 by intratracheal instillation

In this work we study the pulmonary toxicological properties of Mitsui-7 and NM-403 using molecular toxicological approach. For this, we exposed Sprague Dawley rats by intratracheal instillation. Lung samples have been collected 3 days after the end of exposure and transcriptomics analysis were performed.本研究采用分子毒理学方法，探究Mitsui-7与NM-403的肺部毒理学特性。为此，我们通过气管滴注方式对Sprague Dawley（SD）大鼠进行染毒，于染毒结束后3天采集肺组织样本，并开展转录组学分析。