Progesterone, via yes-associated protein (YAP), promotes cardiomyocyte proliferation and cardiac repair

To explore effect of progesterone on gene expression of primary cultured cardiomyocytes isolated from 7-day-old SD rats We isolated and cultured cardiomyocytes using 7-day-old SD rats and treated cells with control vehicle (control) or progesterone (10-7 M) (progesterone) for 24 hours to prepare sample (three biological replicates for each group) and RNA-sequencing (RNA-Seq) were performed using mRNA extracted from these samples.