Collection of putative promoter sequence of genes on different chromosomes of the human genome

Promoter serve as communication
link between protein-based regulatory control systems and nucleotide-based
sequence determinants that regulate gene expression. As such, promoters should
be relatively well characterised as stretches of DNA sequence with transcription
factor binding motifs should be candidates for promoter sequence for specific
genes. But, the perennial problem of defining the start and end nucleotide of
promoter remains unresolved, and promoter sequences for both prokaryotic and
eukaryotic systems remain poorly defined. This work took the oft-used approach
of estimating promoter sequence of genes by characterising 800 base pair sequence
upstream of the gene start site as putative promoter sequence for all genes in
the human genome. Using an in-house MATLAB genome analysis software, the start
site and gene sequence of each gene in the human genome is determined, which
provides foundational knowledge for estimating putative promoter sequence of
each gene in the human genome. Defined in this way, putative promoter sequence
should contain extraneous elements, but, these promoter sequences remain useful
for initial characterisation of the functional basis of specific promoter of
particular gene such as understanding the repertoire of transcription factors
that bind to each promoter, as well as their qualitative binding affinity. The
collection of promoter sequence of each gene in the human genome reported
herein is catalogued based on each chromosome in the karyotype of humans, and
may be useful for understanding possible chromosomal specificities in the
sequence of promoters in the human genome.