RNA-seq analysis of AML cells in response to ASLAN003. RNA-seq analysis of AML cells in response to ASLAN003

We aim to gain insight into the changes of gene expression induced by ASLAN003, a novel, potent Dihydroorotate Dehydrogenase (DHODH) Inhibitor Overall design: AML cell lines KG-1 and MOLM-14 cells treated with DMSO and ASLAN003 for 96 hours. Each treatment was triplicated. RNA was extracted and RNA-seq libraries were constructed by TruSeq Library Prep Kit and subjected to Illumina Hiseq4000 deep sequencing (paired-end reads of 100 bases).