DNA Methylation Profiling in Rare Sellar Esthesioneuroblastoma

Histologic diagnosis of sellar masses can be challenging, particularly in rare neoplasms and tumors without definitive biomarkers. DNA methylation has recently emerged as a useful diagnostic tool. To illustrate the clinical utility of machine-learning-based DNA methylation classifiers, we report a rare case of primary sellar esthesioneuroblastoma diagnosed by DNA methylation classificiation but histologically mimicking a nonfunctioning pituitary adenoma. This is a case report in which DNA methylation data was obtained using illumina arrays on a single tissue sample obtained from a mass of the sella turcica.