Whole?Exome Sequencing Analyses in a Saudi Ischemic Stroke Cohort Reveal Association Signals, and shows Polygenic Risk Scores are related to modified Rankin Scale Risk

Ischemic stroke (IS) represents a significant societal burden across the globe. Rare high penetrant monogenic variants and less pathogenic common single nucleotide polymorphisms (SNPs) have been described with risk of disease. Consanguineous populations from Saudi Arabia offer a greater opportunity to detect rare high penetrant mutations enriched in tribal populations.