Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection

Using the Olink Explore 1536 platform, we measured 1,463 unique proteins in 303 cerebrospinal fluid (CSF) specimens from four clinical centers contributed by uninfected controls and 12 groups of people living with HIV-1 infection representing the spectrum of progressive untreated and treated chronic infection. We present three initial analyses of these measurements: an overview of the CSF protein features of the sample; correlations of the CSF proteins with CSF HIV-1 RNA and neurofilament light chain protein concentrations; and comparison of CSF proteins in HIV-associated dementia (HAD) and neurosymptomatic CSF escape (NSE). These reveal a complex but coherent picture of CSF protein changes with highest concentrations of many proteins during CNS injury in the HAD and NSE groups and variable protein changes across the course of systemic HIV-1 progression that included two common patterns, designated as lymphoid and myeloid patterns, related to principal involvement of their underlying in..., This was an exploratory study using archived CSF samples from four clinical research centers. CSF was collected using standard protocols and stored after low speed centrifugation. Samples were selected from frozen archives at random to represent defined clinical catogories. Proteins were measured using the Olink Explore 1536 platform. The initial description of this study is now in press in PLOS Pathogens, titled Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection. This entry includes the full dataset for this study and this initial manuscript., , # Data from: Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection

[https://doi.org/10.5061/dryad.x3ffbg7tv](https://doi.org/10.5061/dryad.x3ffbg7tv)

## Description of the data and file structure

**S1-Table. Full dataset for the study and MS: *Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection*.**

This table contains the full dataset related to a study measuring a large number of CSF proteins across a wide range of clinical settings of HIV-1 infection. The study and the general features of the changes in these proteins is described in our manuscript, *Changes in Cerebrospinal Fluid Proteins across the Spectrum of Untreated and Treated Chronic HIV-1 Infection*, that is now in press in PLOS Pathogens. This paper introduces the dataset and provides some initial analyses, but the dataset is amenable to additional studies. We invite other investigators to join us in exploiting...