Data from: Phase-dependent differential in vitro and ex vivo susceptibility of Aspergillus flavus and Fusarium keratoplasticum to azole antifungals

Fungal keratitis (FK) is an invasive infection of the cornea primarily
associated with Aspergillus and Fusarium species. FK is treated
empirically with a limited selection of topical antifungals with varying
levels of success. Though clinical infections are typically characterized
by a dense network of mature mycelium, traditional models used to test
antifungal susceptibility of FK isolates exclusively evaluate
susceptibility in fungal cultures derived from asexual spores known as
conidia. The purpose of this study was to characterize differences in
fungal response when topical antifungal treatment is initiated at
progressive phases of fungal development. We compared efficacy of
voriconazole and luliconazole against in vitro cultures of A. flavus and
F. keratoplasticum at 0, 24, and 48 h of fungal development. Data
from this assay is included here, reported as end-point absorbance
values. A porcine cadaver corneal model was used to compare
antifungal efficacy of voriconazole and luliconazole in ex vivo tissue
cultures of A. flavus and F. keratoplasticum at 0, 24, and 48 h of fungal
development. Data from this assay may be found here, reported as pixel
counts of the determined area.