Lipidomic data of the kidney cortex from diabetic mice fed MUFA-HFD and SFA-HFD

In diabetic patients, dyslipidemia frequently
contributes to organ damage such as diabetic kidney
disease (DKD). DKD is associated with excessive renal deposition of
triacylglycerol (TAG) in lipid droplets (LD). Yet, it is unclear whether
LDs play a protective or damaging role and how this might be influenced by
dietary patterns. By using a diabetes mouse model, we find here that
high-fat diet enriched in the unsaturated oleic acid (OA) caused more
lipid storage in LDs in renal proximal tubular cells (PTC) but less
tubular damage than a corresponding butter diet with the saturated
palmitic acid (PA). In order to study the changes in the lipidome, we
performed shotgun lipidomics on the kidney cortex of these mice.