mRNA expression data from macrophages in malignant pleural effusion of wild type and IL-10 deficency mice

Malignant pleural effusion (MPE) is a common medical problem caused by multiple malignancies especially lung cancers and always along with a poor therapeutic outcome.Interlukin-10 (IL-10) promotes the formation and development of malignant pleural effusion (MPE). In the current study, our results showed that IL-10 deficiency decreased the percentage of macrophages in mice MPE and regulated M1/M2 polarization in vivo and vitro. The migration capacity of tumor cells was suppressed, and apoptosis was promoted when co-cultured with MPE macrophages in the absence of IL-10. Overall design: MPE macrophages from WT and IL-10-/- mice were collected for RNA extraction.The mRNA profiles were sequenced using an Illumina HiSeq sequencer with pair end 150 bp reading length (Illumina, San Diego, CA).