Genes regulated by COUP-TFII inhibitor

The orphan nuclear receptor COUP-TFII is expressed at a low level in adult tissues, but its expression is increased and shown to promote progression of multiple diseases including prostate cancer, heart failure and muscular dystrophy. Suppression of COUP-TFII slows disease progression, making it an intriguing therapeutic target. Here, we identified a potent and specific COUP-TFII inhibitor through high-throughput screening. The inhibitor specifically suppressed COUP-TFII activity to regulate its target genes. mRNA profiles of LNCaP cells treated with COUP-TFII inhibitor for 18 hours or transfected with siCOUP-TFII for 72 hours. RNA-sequencing and analysis was performed by EA | Q² Solutions, Morrisville, NC 27560.