Smad1

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Involved in several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; osteoblast differentiation; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including brain development; positive regulation of macromolecule biosynthetic process; and skeletal system development. Located in cytoplasm and nucleus. Part of homomeric SMAD protein complex and transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SMAD1 (SMAD family member 1). [provided by Alliance of Genome Resources, Nov 2024]

激活DNA结合转录因子活性，RNA聚合酶II特异性；相同蛋白结合活性；以及核酸结合活性。参与多个过程，包括细胞表面受体蛋白丝氨酸/苏氨酸激酶信号通路；成骨细胞分化；以及miRNA转录的正调控。在多个过程中发挥上游作用或存在于其中，包括大脑发育；大分子生物合成过程的正调控；以及骨骼系统发育。位于细胞质和细胞核中。为同源SMAD蛋白复合物和转录调控复合物的一部分。在多个结构中表达，包括消化系统；早期胚胎；泌尿生殖系统；神经系统；以及感觉器官。与人源SMAD1（SMAD家族成员1）同源。[由基因组资源联盟提供，2024年11月]