RB1 translocates to the nucleus
收藏reactome.org2025-03-23 收录
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Amino acid residues 860-876 in the C terminal part of RB1 constitute a bipartite nuclear localization signal (NLS), needed for translocation of RB1 from the cytosol to the nucleus. In the absence of the NLS, only a small portion of RB1 translocates to the nucleus, while a large portion of RB1 is retained in the cytosol (Zacksenhaus et al. 1993).
在RB1的C端结构域中,氨基酸残基860-876区域构成了一个双组分核定位信号(NLS),此信号对于RB1从细胞质向细胞核的转移至关重要。在NLS缺失的情况下,仅有少量RB1能够转移到细胞核中,而大量RB1则保留在细胞质中(Zacksenhaus等,1993年)。
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