Effect of depletion of USP22 on gene expression of A375 melanoma cell line

To investigate the function USP22 in the regulation of tumor progression, we established A375 cell lines in which each target gene has been knocked down by shRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cells and 3 repeated samples for each cell. Overall design: Comparative gene expression profiling analysis of RNA-seq data for A375 cells and its KD derivative (shUSP22).