Overview of the phenotypic comparisons between Apc+/1572T and other Apc-mutant mouse models.

Notes: Incidence is given as percentage of affected animals.1,3Animals were sacrificed when signs of discomfort were apparent and/or when tumor size reached 2 cm.2The incidence of GI tumors was calculated after exclusion of the pyloric lesions as these present in clusters often difficult to count.3The multiplicity of GI tumors was calculated based on all animals with the exception of those where the high tumor burden made the count not feasible.*This specific animal was found to carry a single tumor at 21 months of age, likely to represent a sporadic case. Background (B) of the different strains analyzed: F1: C57Bl6/J x 129Ola; Ola: inbred 129Ola; B6: inbred C57Bl6/J. n.d. not determined.