EDNRA gene rs1878406 polymorphism is associated with susceptibility to large artery atherosclerotic stroke. EDNRA gene rs1878406 polymorphism

Objective: We performed this study to investigate whether the EDNRA gene rs1878406 C >T polymorphism is associated with risk of large artery atherosclerosis (LAA) stroke in Chinese Han population. Methods: Genotyping of rs1878406 was performed in 1112 LAA stroke patients and 1192 healthy controls. Multivariate logistic regression analyses were applied to assess the effect of the rs1878406 C >T polymorphism on susceptibility to LAA stroke. Results: A significant increase of LAA stroke risk was found in the recessive model (TT vs. CC/TC, OR=1.74, 95%CI=1.23-2.48, P=0.002) and co-dominant model (TC vs. CC, OR=1.06, 95% CI=0.89-1.27, TT vs. CC, OR=1.79, 95% CI=1.25-2.55, P=0.006) . However, the interaction between age and genotypes of rs1878406 was not statistically significant, and no significant interactive effect was observed between the rs1878406 C > T polymorphism and sex (P > 0.05). Conclusion: The rs1878406 C >T polymorphism is associated with increased risk of LAA stroke in the Chinese Han population. Keywords : polymorphism; large artery atherosclerosis; genotype;stroke; rs1878406