A cellular model of the oncogenic FOXL2 somatic pathogenic variant C134W provides new insights in pathogenicity

To investigate the dysfunction of FOXL2-C134W in human granulosa cells, we established homozygous cell lines for FOXL2 WT by CRISPR/Cas9 technologies. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different clones (FOXL2 WT/WT vs FOXL2 WT/Mut).